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Hereditary Cancer Testing with PsiGenex

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What is Comprehensive Hereditary Cancer Testing?

Clinical guidelines recommend comprehensive multi-gene testing over single-gene testing when more than one gene can explain an inherited cancer syndrome. The Comprehensive Hereditary Cancer Panel from PsiGenex provides you with more insight to help you identify the most cancer syndromes.

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Comprehensive Hereditary Cancer Testing

What is Organ and System Specific Cancer Testing?

PsiGenex allows for a more targeted approach by offering nine hereditary cancer panels that are specific to each cancer type. These panels cover all of the high penetrance genes as well as other medium risk genes that have well-established evidence of association with common cancer syndromes.

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Organ and System Specific Cancer Testing

Cancer is caused by changes, or variants, that occur in our genes. Some we
are born with, some we develop randomly. Here's the difference:

Sporadic

Family Tree diagram showing one person highlighted out of 11 shown in 3 generations

The majority of cancer-causing variants are sporadic, meaning that they occur randomly as a result of age and environmental exposures. Cancers caused by sporadic variants typically appear later in life and with little or no family history.

Signs of Sporadic Cancer

Later ages of onset (60’s-70’s)
Little or no family history of cancer
Single or unilateral cancers

Hereditary

Family Tree diagram showing 4 person highlighted out of 11 shown in 3 generations

Hereditary mutations are present from birth, generally having been inherited from a parent, and can continue to be passed down through generations. People born with these cancer-causing variants have a greater likelihood of developing cancer than the general population.

Signs of Hereditary Cancer:

Early ages of onset (under 50’s)
Multiple generations with cancer
Multiple or bilateral cancers
Clustering of certain cancers (e.g. breast and ovarian)

Early Detection is Key

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Five year survival rates comparison for early vs late cancer detection

Comprehensive Hereditary Cancer Panel

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54 Genes

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32 Hereditary Cancer Syndromes

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9 Different Organ Systems

Reasons to Consider a Comprehensive Multi-Gene Panel:

  • Help your health care team decide what cancer screenings you might need beyond routine screenings.
  • Multi-gene testing is more efficient and cost-effective because some insurance companies will not cover repeat testing if single/limited gene testing results are negative.
  • The clinical presentations of various hereditary cancer syndromes can overlap, so comprehensive testing allows for simultaneous evaluation of multiple genes or syndromes.
  • A negative result on a multi-gene panel is more reassuring than a negative result for one or a few genes. In addition, panel testing can identify a syndrome that was not your first differential and may have been missed with single gene testing.
See Full Gene List

Comprehensive Multi-Organ Hereditary Cancer Risk Assessment Panel

Organ and System Specific Cancer Testing

PsiGenex offers nine organ and system specific panels, covering the most common hereditary cancer syndromes. With these, only genes that are relevant to that selected cancer are assessed.

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  • BRCA1 and BRCA2
  • Hereditary Breast Cancer
  • Hereditary Colorectal Cancer
  • Hereditary Endometrial Cancer
  • Hereditary Gastric Cancer
  • Hereditary Melanoma
  • Hereditary Ovarian Cancer
  • Hereditary Pancreatic Cancer
  • Hereditary Prostate Cancer
See Panel Specific Details

The PsiGenex Advantage

PsiGenex is a premier laboratory that brings together industry leading expertise with state-of-the-art technologies to provide unparalleled precision testing to our clinicians and their patients.

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Actionable Reporting

With vast coverage of medically relevant genes and high sensitivity achieved through Next Generation Sequencing, our tests provide reports that allow patients to take action for their health.

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Industry Leading Turnaround Time

Results this important can’t wait. We are committed to providing most test results in under a week.

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Compassionate Billing

Our billing team works with every patient to ensure they have access to premium comprehensive genetic testing, regardless of insurance coverage.

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Accessible Medical Team

In an effort to help navigate the complexities of genetic testing, we provide complimentary genetic counseling services and are here to answer any questions about our testing process.