Better Pregnancy Outcomes with PGT-A
What is PGT-A (for Aneuploidy)?
PGT-A is a genetic assay that tests embryos for chromosome aneuploidy such as Trisomy or Monosomy. The purpose of PGT-A is to increase a patient’s chance of achieving a successful pregnancy by selecting chromosomally normal embryos for implantation.
Who is a Good Candidate for PGT-A?
All patients undergoing IVF could benefit from PGT-A, regardless of age, however, PGT-A is highly recommended for the following indications:
- A couple with a history of multiple miscarriages
- A couple with a history of IVF failure
- A couple with a history of a previous pregnancy or an offspring with chromosomal abnormalities
- A male partner with severe infertility
The PGT-A Process
What is PGT-M (for Monogenic Disorders)?
In cases where the patient is known to be at increased risk of having a child with a monogenic or single gene genetic disorder, typically from either having a personal or family history of that condition or having positive carrier screening results, PGT-M can be performed. These genetic conditions cannot be detected with PGT-A.
PGT-M can be done at the same time as PGT-A, on the same embryo, and combined would help to select an embryo that both did not inherit the known genetic trait and has the correct number of chromosomes.
Who is a Good Candidate for PGT-M?
PGT-M is indicated for those at risk of passing single gene disorders. This includes:
- Mother is a carrier of an X-linked condition such as Fragile X
- Both biological parents are carriers of an autosomal recessive condition such as Cystic Fibrosis
- Either biological parent carries a cancer-cause gene mutation such as a BRCA mutation
- Either biological parent has an autosomal dominant condition such as Huntington’s Disease
- There is a reproductive history of a single gene disorder
The PGT-M Process
What is PGT-SR (for Structural Rearrangements)?
Patients that are known to carry a balanced chromosomal rearrangement such as a translocation or inversion can benefit from PGT-SR. This information may have been obtained from family history, from a karyotype test performed after recurrent miscarriages, a previous pregnancy or child with chromosomal rearrangement, or as part of an infertility workup. Carriers of balanced chromosomal rearrangements are typically healthy, but are at risk of having unsuccessful pregnancies or children with genetic disorders.
Who is a Good Candidate for PGT-SR?
PGT-SR is for patients who have had a karyotype which revealed:
The PGT-SR Process
The standard IVF procedure is performed.
At around day five after fertilization, 5-6 cells are retrieved from the blastocyst’s trophectoderm layer, which gives rise to the placenta, maintaining the inner mass's integrity, which gives rise to the fetus. Embryos are frozen at your IVF laboratory while testing is being performed.
Embryo biopsies are sent frozen for testing. PGT-SR is performed, and a comprehensive report is generated.