Skip to Main Content
Preimplantation Genetic Testing

PGT Evaluates Embryo Biopsies Created Through IVF

PGT-A
(Aneuploidy)

Screens for the presence of all 46 chromosomes

Learn More About PGT-A

PGT-M
(Monogenic)

Screens for single gene conditions

Learn More About PGT-M

PGT-SR
(Structural Rearrangements)

Screens for chromosomal rearrangements

Learn More About PGT-SR

 

The Benefits of PGT Testing

PGT - PsiGenex - lower1

Decreasing the chance of having a child with a chromosomal disorder.

PGT - PsiGenex - 1pgt3

Reducing miscarriage rate.

PGT - PsiGenex - 1pgt1

Increasing implantation & pregnancy rates as well as the chance of a live birth.

PGT - PsiGenex - time2

Reducing the time to pregnancy.

PGT - PsiGenex - 1pgt2

Reducing the cost and anxiety from repeated IVF cycles.

Better Pregnancy Outcomes with PGT-A

PGT - PsiGenex - birth-chart1

What is PGT-A (for Aneuploidy)?

PGT-A is a genetic assay that tests embryos for chromosome aneuploidy such as Trisomy or Monosomy. The purpose of PGT-A is to increase a patient’s chance of achieving a successful pregnancy by selecting chromosomally normal embryos for implantation.

Who is a Good Candidate for PGT-A?

All patients undergoing IVF could benefit from PGT-A, regardless of age, however, PGT-A is highly recommended for the following indications:

  • A couple with a history of multiple miscarriages
  • A couple with a history of IVF failure
  • A couple with a history of a previous pregnancy or an offspring with chromosomal abnormalities
  • A male partner with severe infertility

The PGT-A Process

IVF
The standard IVF procedure is performed at your office. It consists of ovarian stimulation, egg retrieval, egg fertilization, and embryo development. PsiGenex provides genetic counseling service to patients who wish to learn more about PGT-A.
Embryo Biopsy
At around day five after fertilization, 5-6 cells are retrieved from the blastocyst's trophectoderm layer, which gives rise to the placenta, maintaining the inner mass's integrity, which gives rise to the fetus. Embryos are frozen at your IVF laboratory while testing is being performed.
PGT-A Testing
Embryo biopsies are sent frozen to PsiGenex for testing. PGT-A is performed, and comprehensive report is generated in 3-5 days after specimen receipt.
Embryo Selection & Transfer
Based on PGT-A results, suitable embryos are selected for transfer.

What is PGT-M (for Monogenic Disorders)?

In cases where the patient is known to be at increased risk of having a child with a monogenic or single gene genetic disorder, typically from either having a personal or family history of that condition or having positive carrier screening results, PGT-M can be performed. These genetic conditions cannot be detected with PGT-A.

PGT-M can be done at the same time as PGT-A, on the same embryo, and combined would help to select an embryo that both did not inherit the known genetic trait and has the correct number of chromosomes.

Who is a Good Candidate for PGT-M?

PGT-M is indicated for those at risk of passing single gene disorders. This includes:

  • Mother is a carrier of an X-linked condition such as Fragile X
  • Both biological parents are carriers of an autosomal recessive condition such as Cystic Fibrosis
  • Either biological parent carries a cancer-cause gene mutation such as a BRCA mutation
  • Either biological parent has an autosomal dominant condition such as Huntington’s Disease
  • There is a reproductive history of a single gene disorder

The PGT-M Process

Custom PGT-M Test is Created
This typically requires a blood sample from each biological parent and may require blood samples from additional family members.
IVF
The standard IVF procedure is performed.
Embryo Biopsy
At around day five after fertilization, 5-6 cells are retrieved from the blastocyst’s trophectoderm layer, which gives rise to the placenta, maintaining the inner mass's integrity, which gives rise to the fetus. Embryos are frozen at your IVF laboratory while testing is being performed.
PGT-M Testing
Embryo biopsies are sent frozen for testing. PGT-M is performed, and a comprehensive report is generated.

What is PGT-SR (for Structural Rearrangements)?

Patients that are known to carry a balanced chromosomal rearrangement such as a translocation or inversion can benefit from PGT-SR. This information may have been obtained from family history, from a karyotype test performed after recurrent miscarriages, a previous pregnancy or child with chromosomal rearrangement, or as part of an infertility workup. Carriers of balanced chromosomal rearrangements are typically healthy, but are at risk of having unsuccessful pregnancies or children with genetic disorders.

Who is a Good Candidate for PGT-SR?

PGT-SR is for patients who have had a karyotype which revealed:

  • Translocations
  • Inversions
  • Deletions
  • Duplications
  • Insertions

The PGT-SR Process

IVF

The standard IVF procedure is performed.

Embryo Biopsy

At around day five after fertilization, 5-6 cells are retrieved from the blastocyst’s trophectoderm layer, which gives rise to the placenta, maintaining the inner mass's integrity, which gives rise to the fetus. Embryos are frozen at your IVF laboratory while testing is being performed.

PGT-SR Testing

Embryo biopsies are sent frozen for testing. PGT-SR is performed, and a comprehensive report is generated.

The PsiGenex Advantage

PsiGenex is a premier laboratory that brings together industry leading expertise with state-of-the-art technologies to provide unparalleled precision testing to our clinicians and their patients.

Template - Content - Advantage Callouts - PsiGenex - icon more coverage

Actionable Reporting

With vast coverage of medically relevant genes and high sensitivity achieved through Next Generation Sequencing, our tests provide reports that allow patients to take action for their health.

Template - Content - Advantage Callouts - PsiGenex - icon industry leading

Industry Leading Turnaround Time

Results this important can’t wait. We are committed to providing most test results in under a week.

Template - Content - Advantage Callouts - PsiGenex - icon actionable reporting

Compassionate Billing

Our billing team works with every patient to ensure they have access to premium comprehensive genetic testing, regardless of insurance coverage.

Template - Content - Advantage Callouts - PsiGenex - icon actionable reports

Accessible Medical Team

In an effort to help navigate the complexities of genetic testing, we provide complimentary genetic counseling services and are here to answer any questions about our testing process.