Our highly sensitive Hereditary Gastric Cancer Panel analyzes 23 genes, covering all high penetrance genes as well as other high and medium risk genes that have well-established evidence of association with hereditary gastric cancer.
Genes Analyzed
| APC | BMPR1A | BRCA1 | BRCA2 | CDH1 | CTNNA1 | EPCAM | KIT |
| MEN1 | MLH1 | MSH2 | MSH6 | MUTYH | NF1 | PDGFRA | PMS2 |
| SDHA | SDHB | SDHC | SDHD | SMAD4 | STK11 | TP53 |
Approximately 10% of gastric cancer is hereditary. The most important susceptibility gene for gastric cancer is the CDH1 gene, however other genes associated with an increased risk include APC, BRCA1, BRCA2, and MSH. Individuals with a pathogenic variant in one of these genes have a significantly increased risk of developing gastric cancer.
Lifetime Cancer Risks
Who Should Get Tested?
Certain red flags indicate a higher risk for hereditary gastric cancer, which include but are not limited to:
- Early-onset gastric cancer.
- Gastric cancer in multiple relatives on the same side of the family.
- Multiple cancers such as breast cancer (particularly lobular type), and other GI tumors in the same individual or in close family members.
- Gastric polyposis.
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